CIK: 1263508
BAKER BROS. ADVISORS LP
Address: 860 WASHINGTON STREET, 3RD FLOOR, NEW YORK, NY 10014
α Alpha 0.86↭ Flow 0.40Mixed Active/Passive
100holdings (Q4 2025)
$17.08B13F reported value
+9 NEW+61 INCREASED-16 DECREASED-14 EXITED
Total (Q4 25): $17,078,624,105
Top Holdings by Value
Position Changes (Q4 vs Q3)
Top 15 Positions ($)
Historical AUM (13F Reported)
$7.97B-$10.41B QoQPortfolio Value History (13F Reported)
Quarterly 13F portfolio value. QoQ change reflects value of disclosed long equity positions (new buys, sells, and price movements combined).
| Quarter | Portfolio Value | QoQ Change | QoQ % |
|---|---|---|---|
| Q4 25 | $17.08B | +$3.24B | +23.4% |
| Q3 25 | $13.84B | +$3.53B | +34.3% |
| Q2 25 | $10.31B | +$1.27B | +14.1% |
| Q1 25 | $9.04B | $-0.32B | -3.5% |
| Q4 24 | $9.36B | $-0.29B | -3.0% |
| Q3 24 | $9.65B | +$1.82B | +23.3% |
| Q2 24 | $7.83B | $-0.15B | -1.8% |
| Q1 24 | $7.97B | $-0.82B | -9.3% |
| Q4 23 | $8.79B | $-8.56B | -49.3% |
| Q3 23 | $17.35B | +$0.07B | +0.4% |
| Q2 23 | $17.28B | $-1.10B | -6.0% |
| Q1 23 | $18.38B | — | — |
QoQ = (quarter 13F value − prior quarter value) ÷ prior quarter value. Includes position changes, new buys, and exits. Not investment advice.
Information for Viewing 13F Reports:
- Name: The name of the company.
- CUSIP: A unique 9-character alphanumeric code that identifies a specific stock or security in the U.S.
- Class: The investment company's series name. A registered investment company may have multiple series, each with a separate securities portfolio.
- Value: The monetary value of the holdings in USD.
- Shares: The number of shares held.
- Share Price: The price of shares at the time of filing.
- Investment: The type of investment.
- % of Portfolio: The percentage that this position represents in the total portfolio.
| Quarter | Period of Report | Holdings | Value | Type | Filling Date | Filling ID |
|---|---|---|---|---|---|---|
| Q4 25 | 31-Dec-2025 | 86 | $17,078,624,105 | 13F-HR | 17-Feb-2026 | 0001104659-26-016374 |
| Q3 25 | 30-Sep-2025 | 91 | $13,838,782,047 | 13F-HR | 14-Nov-2025 | 0001104659-25-112595 |
| Q2 25 | 30-Jun-2025 | 89 | $10,307,840,459 | 13F-HR | 14-Aug-2025 | 0001104659-25-078573 |
| Q1 25 | 31-Mar-2025 | 89 | $9,036,702,464 | 13F-HR | 15-May-2025 | 0001104659-25-049518 |
| Q4 24 | 31-Dec-2024 | 95 | $9,361,492,374 | 13F-HR | 14-Feb-2025 | 0001104659-25-014085 |
| Q3 24 | 30-Sep-2024 | 93 | $9,648,757,562 | 13F-HR | 14-Nov-2024 | 0001104659-24-118899 |
| Q2 24 | 30-Jun-2024 | 95 | $7,825,077,664 | 13F-HR | 14-Aug-2024 | 0001104659-24-089606 |
| Q1 24 | 31-Mar-2024 | 87 | $7,971,707,022 | 13F-HR | 15-May-2024 | 0001104659-24-061996 |
| Q4 23 | 31-Dec-2023 | 84 | $8,788,600,529 | 13F-HR | 14-Feb-2024 | 0001104659-24-024053 |
| Q3 23 | 30-Sep-2023 | 101 | $17,351,037,330 | 13F-HR | 14-Nov-2023 | 0001104659-23-118157 |
| Q2 23 | 30-Jun-2023 | 107 | $17,279,240,811 | 13F-HR | 14-Aug-2023 | 0001104659-23-091343 |
| Q1 23 | 31-Mar-2023 | 105 | $18,379,748,932 | 13F-HR | 15-May-2023 | 0001104659-23-060720 |
| Q4 22 | 31-Dec-2022 | 113 | $16,651,382,602 | 13F-HR | 14-Feb-2023 | 0001104659-23-021551 |
| Q3 22 | 30-Sep-2022 | 115 | $15,269,446,000 | 13F-HR | 14-Nov-2022 | 0001104659-22-118527 |
| Q2 22 | 30-Jun-2022 | 117 | $17,626,987,000 | 13F-HR | 15-Aug-2022 | 0001104659-22-091286 |
| Q1 22 | 31-Mar-2022 | 118 | $17,403,462,000 | 13F-HR | 16-May-2022 | 0001104659-22-061288 |
| Q4 21 | 31-Dec-2021 | 121 | $20,553,592,000 | 13F-HR | 14-Feb-2022 | 0001104659-22-022725 |
| Q3 21 | 30-Sep-2021 | 122 | $22,771,634,000 | 13F-HR | 15-Nov-2021 | 0001104659-21-139109 |
| Q2 21 | 30-Jun-2021 | 120 | $22,769,898,000 | 13F-HR | 16-Aug-2021 | 0001104659-21-106314 |
| Q1 21 | 31-Mar-2021 | 126 | $23,065,323,000 | 13F-HR | 17-May-2021 | 0001104659-21-068025 |
| Q4 20 | 31-Dec-2020 | 126 | $26,543,637,000 | 13F-HR | 16-Feb-2021 | 0001104659-21-023833 |
| Q3 20 | 30-Sep-2020 | 120 | $25,025,928,000 | 13F-HR | 16-Nov-2020 | 0001104659-20-125767 |
| Q2 20 | 30-Jun-2020 | 114 | $22,670,991,000 | 13F-HR | 14-Aug-2020 | 0001104659-20-095518 |
| Q1 20 | 31-Mar-2020 | 110 | $16,236,233,000 | 13F-HR | 15-May-2020 | 0001104659-20-062575 |
| Q4 19 | 31-Dec-2019 | 99 | $18,809,854,000 | 13F-HR | 14-Feb-2020 | 0001104659-20-021838 |
| Q3 19 | 30-Sep-2019 | 109 | $14,699,689,000 | 13F-HR | 14-Nov-2019 | 0001104659-19-064169 |
| Q2 19 | 30-Jun-2019 | 103 | $14,714,211,000 | 13F-HR | 14-Aug-2019 | 0001144204-19-040033 |
| Q1 19 | 31-Mar-2019 | 96 | $15,621,759,000 | 13F-HR | 15-May-2019 | 0001144204-19-026555 |
| Q4 18 | 31-Dec-2018 | 93 | $12,212,527,000 | 13F-HR | 13-Feb-2019 | 0001144204-19-007156 |
| Q3 18 | 30-Sep-2018 | 97 | $15,181,170,000 | 13F-HR | 14-Nov-2018 | 0001144204-18-059891 |
| Q2 18 | 30-Jun-2018 | 119 | $13,308,803,000 | 13F-HR | 14-Aug-2018 | 0001144204-18-044607 |
| Q1 18 | 31-Mar-2018 | 114 | $11,797,988,000 | 13F-HR | 15-May-2018 | 0001144204-18-028818 |
| Q4 17 | 31-Dec-2017 | 123 | $11,537,077,000 | 13F-HR | 14-Feb-2018 | 0001144204-18-008839 |
| Q4 16 | 31-Dec-2016 | 133 | $10,200,965 | 13F-HR | 14-Feb-2017 | 0001144204-17-008836 |
| Q3 16 | 30-Sep-2016 | 134 | $11,019,928 | 13F-HR | 14-Nov-2016 | 0001144204-16-134352 |
| Q2 16 | 30-Jun-2016 | 135 | $9,537,918 | 13F-HR | 15-Aug-2016 | 0001144204-16-119409 |
| Q1 16 | 31-Mar-2016 | 134 | $9,482,104 | 13F-HR | 16-May-2016 | 0001144204-16-102596 |
| Q4 15 | 31-Dec-2015 | 133 | $12,071,272 | 13F-HR | 16-Feb-2016 | 0001144204-16-082790 |