PRLD PRELUDE THERAPEUTICS INC
COMMON
CUSIP: 74065P101
FIGI: BBG00K7JY2Q6
Institutional Holders47
Total Institutional Value$78,876,227
Total Shares Held28,491,163
Avg Position$1,678,218
Top 5 Holders %88.3%
Alpha-Weighted Score76.4
New Positions+10
Exited Positions-10
Top 15 Institutional Holders by Value
■ New ■ Increased ■ Decreased ■ Unchanged
Institutional Holders — Q4 25
| Manager | Alpha | Flow | Value | Shares | Change |
|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | High Conviction | Low Flow | $31,636,842 (40.1%) | 10,909,256 | 101.4% |
| BAKER BROS. ADVISORS LP | Elite Conviction | Moderate Flow | $29,359,090 (37.2%) | 10,123,824 | 101.4% |
| VANGUARD GROUP INC | High Conviction | Market Mover | $4,100,559 (5.2%) | 1,413,986 | 186.8% |
| KYNAM CAPITAL MANAGEMENT, LP | Elite Conviction | Low Flow | $2,287,714 (2.9%) | 788,867 | NEW |
| TWO SIGMA INVESTMENTS, LP | Moderate Conviction | Significant Flow | $2,287,216 (2.9%) | 788,695 | 943.4% |
| MORGAN STANLEY | Moderate Conviction | Market Mover | $971,257 (1.2%) | 334,916 | 137.3% |
| MARSHALL WACE, LLP | Moderate Conviction | Market Mover | $794,260 (1.0%) | 273,883 | NEW |
| GEODE CAPITAL MANAGEMENT, LLC | High Conviction | Market Mover | $791,502 (1.0%) | 272,886 | 152.6% |
| RENAISSANCE TECHNOLOGIES LLC | High Conviction | Significant Flow | $786,770 (1.0%) | 271,300 | - |
| BLACKROCK FUNDING, INC. /DE | High Conviction | Market Mover | $772,212 (1.0%) | 266,280 | 102.4% |
| TWO SIGMA ADVISERS, LP | High Conviction | Significant Flow | $688,170 (0.9%) | 237,300 | 114.6% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Moderate Conviction | Market Mover | $488,386 (0.6%) | 168,409 | NEW |
| TD ASSET MANAGEMENT INC | High Conviction | Significant Flow | $465,891 (0.6%) | 160,652 | 101.4% |
| MILLENNIUM MANAGEMENT, L.L.C. | Moderate Conviction | Market Mover | $437,891 (0.6%) | 150,997 | -73.5% |
| STATE STREET CORP | High Conviction | Market Mover | $369,147 (0.5%) | 127,292 | 162.7% |
| SPHERA FUNDS MANAGEMENT LTD. | High Conviction | Minimal Flow | $355,981 (0.5%) | 122,752 | NEW |
| GOLDMAN SACHS GROUP INC | High Conviction | Market Mover | $340,683 (0.4%) | 117,477 | 198.2% |
| JANE STREET GROUP, LLC | Moderate Conviction | Market Mover | $322,016 (0.4%) | 111,040 | 542.2% |
| ONTARIO MUNICIPAL EMPLOYEE RETIREMENT BOARD | High Conviction | Significant Flow | $211,700 (0.3%) | 73,000 | NEW |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | High Conviction | Market Mover | $200,428 (0.3%) | 70,546 | 101.0% |
| POINT72 ASSET MANAGEMENT, L.P. | Moderate Conviction | Market Mover | $171,587 (0.2%) | 59,168 | NEW |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | High Conviction | Moderate Flow | $155,150 (0.2%) | 53,500 | 101.4% |
| XTX TOPCO LTD | Moderate Conviction | Moderate Flow | $145,461 (0.2%) | 50,159 | 548.5% |
| NORTHERN TRUST CORP | High Conviction | Market Mover | $145,348 (0.2%) | 50,120 | 177.1% |
| COLONY GROUP, LLC | High Conviction | Significant Flow | $145,020 (0.2%) | 50,007 | NEW |
| CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD. | High Conviction | Significant Flow | $133,661 (0.2%) | 46,090 | NEW |
| HPM PARTNERS LLC | High Conviction | Market Mover | $95,564 (0.1%) | 32,953 | 93.3% |
| QUBE RESEARCH & TECHNOLOGIES LTD | Moderate Conviction | Market Mover | $62,498 (0.1%) | 21,551 | NEW |
| PRUDENTIAL FINANCIAL INC | High Conviction | Significant Flow | $45,008 (0.1%) | 15,520 | 21.0% |
| BANK OF AMERICA CORP /DE/ | Moderate Conviction | Market Mover | $28,443 (0.0%) | 9,808 | 11.6% |
| BARCLAYS PLC | High Conviction | Market Mover | $24,946 (0.0%) | 8,602 | 98.9% |
| FMR LLC | High Conviction | Market Mover | $17,841 (0.0%) | 6,152 | 36.2% |
| SBI SECURITIES CO., LTD. | High Conviction | Moderate Flow | $7,949 (0.0%) | 2,741 | 101.4% |
| CALDWELL SUTTER CAPITAL, INC. | High Conviction | Low Flow | $5,800 (0.0%) | 2,000 | NEW |
| UBS Group AG | Moderate Conviction | Market Mover | $5,385 (0.0%) | 1,857 | -10.3% |
| ROYAL BANK OF CANADA | High Conviction | Market Mover | $5,000 (0.0%) | 1,742 | -66.7% |
| NISA INVESTMENT ADVISORS, LLC | Elite Conviction | Significant Flow | $4,739 (0.0%) | 1,634 | 101.4% |
| PNC FINANCIAL SERVICES GROUP, INC. | High Conviction | Market Mover | $3,396 (0.0%) | 1,171 | 101.4% |
| PRICE T ROWE ASSOCIATES INC /MD/ | High Conviction | Moderate Flow | $2,193 (0.0%) | 755,956 | 73.8% |
| ACADIAN ASSET MANAGEMENT LLC | High Conviction | Low Flow | $1,551 (0.0%) | 535,703 | 99.6% |
| GROUP ONE TRADING, L.P. | Moderate Conviction | Significant Flow | $1,450 (0.0%) | 500 | 101.4% |
| BNP PARIBAS FINANCIAL MARKETS | Moderate Conviction | Market Mover | $276 (0.0%) | 95 | 268.0% |
| JPMORGAN CHASE & CO | High Conviction | Market Mover | $180 (0.0%) | 62 | -98.4% |
| OPTIVER HOLDING B.V. | High Conviction | Significant Flow | $58 (0.0%) | 20 | 100.0% |
| CITIGROUP INC | Moderate Conviction | Market Mover | $3 (0.0%) | 1 | -100.0% |
| IFP ADVISORS, INC | High Conviction | Moderate Flow | $3 (0.0%) | 1 | -88.5% |
| CWM, LLC | Moderate Conviction | Low Flow | $2 (0.0%) | 692 | - |
Implied Institutional Price History
Estimated from 13F aggregate market value ÷ shares reported across all institutional filers. Reflects quarter-end snapshot, not actual trade prices.
| Quarter | Filers | Institutional Value | Shares Held | Est. Avg Price |
|---|---|---|---|---|
| Q4 25 | 47 | $0.08B | 28,491,120 | $2.77 |
| Q3 25 | 47 | $0.04B | 27,404,318 | $1.37 |
| Q2 25 | 49 | $0.02B | 27,196,557 | $0.76 |
| Q1 25 | 57 | $0.03B | 30,831,889 | $0.84 |
| Q4 24 | 61 | $0.04B | 32,833,408 | $1.21 |
| Q3 24 | 69 | $0.07B | 36,453,488 | $1.93 |
| Q2 24 | 60 | $0.13B | 34,518,037 | $3.71 |
| Q1 24 | 57 | $0.16B | 34,814,948 | $4.57 |
Source: SEC 13F-HR filings. Implied price = aggregate market value ÷ shares reported. Not investment advice.