BCRX BIOCRYST PHARMACEUTICALS INC
COM
CUSIP: 09058V103
FIGI: BBG000BLYWX6
Institutional Holders276
Total Institutional Value$1,606,207,236
Total Shares Held210,567,068
Avg Position$5,819,591
Top 5 Holders %41.1%
Alpha-Weighted Score68.3
New Positions+45
Exited Positions-56
Top 15 Institutional Holders by Value
■ New ■ Increased ■ Decreased ■ Unchanged
Institutional Holders — Q4 25
| Manager | Alpha | Flow | Value | Shares | Change |
|---|---|---|---|---|---|
| VANGUARD GROUP INC | High Conviction | Market Mover | $173,732,325 (10.8%) | 22,273,375 | 5.0% |
| BLACKROCK FUNDING, INC. /DE | High Conviction | Market Mover | $164,874,767 (10.3%) | 21,137,791 | 2.2% |
| RA CAPITAL MANAGEMENT, LLC | Elite Conviction | Low Flow | $123,452,051 (7.7%) | 15,827,186 | NEW |
| DEERFIELD MANAGEMENT/NY | High Conviction | Low Flow | $111,859,800 (7.0%) | 14,341,000 | 21.1% |
| STATE STREET CORP | High Conviction | Market Mover | $86,371,046 (5.4%) | 11,073,211 | 16.0% |
| KYNAM CAPITAL MANAGEMENT, LP | Elite Conviction | Low Flow | $73,058,903 (4.5%) | 9,366,526 | 2.5% |
| JANUS HENDERSON GROUP PLC | High Conviction | Market Mover | $57,791,233 (3.6%) | 7,404,386 | 8,036.6% |
| UBS Group AG | Moderate Conviction | Market Mover | $41,120,929 (2.6%) | 5,271,914 | -9.3% |
| GEODE CAPITAL MANAGEMENT, LLC | High Conviction | Market Mover | $39,426,800 (2.5%) | 5,053,786 | 2.8% |
| TWO SIGMA INVESTMENTS, LP | Moderate Conviction | Significant Flow | $35,219,473 (2.2%) | 4,515,317 | 5.0% |
| TWO SIGMA ADVISERS, LP | High Conviction | Significant Flow | $31,895,074 (2.0%) | 4,089,112 | - |
| Nuveen, LLC | High Conviction | Market Mover | $28,176,454 (1.8%) | 3,612,366 | 2.6% |
| GOLDMAN SACHS GROUP INC | High Conviction | Market Mover | $25,059,723 (1.6%) | 3,212,785 | 21.8% |
| PERCEPTIVE ADVISORS LLC | High Conviction | Low Flow | $24,667,726 (1.5%) | 3,162,529 | NEW |
| EVERSEPT PARTNERS, LP | High Conviction | Low Flow | $23,344,581 (1.5%) | 2,992,895 | 123.9% |
| BAKER BROS. ADVISORS LP | Elite Conviction | Moderate Flow | $22,017,271 (1.4%) | 2,822,727 | NEW |
| BNP PARIBAS FINANCIAL MARKETS | Moderate Conviction | Market Mover | $19,833,169 (1.2%) | 2,542,714 | 24.8% |
| FISHER INVESTMENTS INC | High Conviction | Significant Flow | $19,247,022 (1.2%) | 2,467,567 | -3.7% |
| VESTAL POINT CAPITAL, LP | High Conviction | Low Flow | $17,550,000 (1.1%) | 2,250,000 | NEW |
| QUBE RESEARCH & TECHNOLOGIES LTD | Moderate Conviction | Market Mover | $16,880,464 (1.1%) | 2,164,162 | -7.7% |
| RENAISSANCE TECHNOLOGIES LLC | High Conviction | Significant Flow | $16,604,804 (1.0%) | 2,128,821 | 2.2% |
| SCHWAB CHARLES INVESTMENT MANAGEMENT INC | High Conviction | Market Mover | $15,638,524 (1.0%) | 2,004,939 | -47.1% |
| RICE JAMES HALL & ASSOCIATES LLC | High Conviction | Low Flow | $14,852,339 (0.9%) | 1,904,146 | 4.1% |
| NORTHERN TRUST CORP | High Conviction | Market Mover | $14,483,844 (0.9%) | 1,856,903 | - |
| STIFEL FINANCIAL CORP | High Conviction | Market Mover | $14,231,233 (0.9%) | 1,824,517 | 2.9% |
| MORGAN STANLEY | Moderate Conviction | Market Mover | $13,615,396 (0.8%) | 1,745,563 | -65.5% |
| ORBIMED ADVISORS LLC | High Conviction | Low Flow | $13,586,040 (0.8%) | 1,741,800 | 98.6% |
| SQUAREPOINT OPS LLC | Moderate Conviction | Significant Flow | $12,941,698 (0.8%) | 1,659,192 | 53.8% |
| JANE STREET GROUP, LLC | Moderate Conviction | Market Mover | $12,070,164 (0.8%) | 1,547,457 | -41.0% |
| BANK OF AMERICA CORP /DE/ | Moderate Conviction | Market Mover | $11,977,344 (0.7%) | 1,535,557 | -58.5% |
| CITADEL ADVISORS LLC | Moderate Conviction | Market Mover | $11,795,176 (0.7%) | 1,512,202 | 3.3% |
| NANTAHALA CAPITAL MANAGEMENT, LLC | High Conviction | Low Flow | $10,579,741 (0.7%) | 1,356,377 | NEW |
| Invesco Ltd. | Moderate Conviction | Market Mover | $10,568,197 (0.7%) | 1,354,897 | 44.7% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Moderate Conviction | Market Mover | $10,361,465 (0.6%) | 1,328,393 | 297.2% |
| SHAW D E & CO INC | Moderate Conviction | Market Mover | $9,730,235 (0.6%) | 1,247,466 | -25.0% |
| DIMENSIONAL FUND ADVISORS LP | High Conviction | Market Mover | $9,585,046 (0.6%) | 1,228,852 | NEW |
| POINT72 ASSET MANAGEMENT, L.P. | Moderate Conviction | Market Mover | $9,465,893 (0.6%) | 1,213,576 | 423.6% |
| JUPITER ASSET MANAGEMENT LTD | High Conviction | Significant Flow | $9,341,428 (0.6%) | 1,197,619 | -40.1% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | High Conviction | Significant Flow | $8,045,606 (0.5%) | 1,031,488 | 186.1% |
| HUDSON BAY CAPITAL MANAGEMENT, L.P. | High Conviction | Significant Flow | $7,935,517 (0.5%) | 1,017,374 | NEW |
| STANDARD LIFE ABERDEEN PLC | High Conviction | Significant Flow | $7,126,025 (0.4%) | 913,593 | NEW |
| JUMP FINANCIAL, LLC | High Conviction | Significant Flow | $7,105,254 (0.4%) | 910,930 | - |
| PARKMAN HEALTHCARE PARTNERS LLC | High Conviction | Low Flow | $7,020,445 (0.4%) | 900,057 | -8.7% |
| JPMORGAN CHASE & CO | High Conviction | Market Mover | $6,578,286 (0.4%) | 843,370 | -61.7% |
| SPHERA FUNDS MANAGEMENT LTD. | High Conviction | Minimal Flow | $6,535,534 (0.4%) | 837,889 | NEW |
| TANG CAPITAL MANAGEMENT LLC | High Conviction | Low Flow | $6,240,000 (0.4%) | 800,000 | 2.8% |
| SUSQUEHANNA PORTFOLIO STRATEGIES, LLC | High Conviction | Moderate Flow | $6,072,464 (0.4%) | 778,521 | NEW |
| PICTET ASSET MANAGEMENT HOLDING SA | High Conviction | Market Mover | $5,711,948 (0.4%) | 740,510 | -36.8% |
| BARCLAYS PLC | High Conviction | Market Mover | $5,665,664 (0.4%) | 726,367 | -4.6% |
| AQR CAPITAL MANAGEMENT LLC | High Conviction | Market Mover | $5,493,470 (0.3%) | 704,291 | -27.6% |
| PDT PARTNERS, LLC | High Conviction | Low Flow | $5,330,645 (0.3%) | 683,416 | 2.8% |
| VOYA INVESTMENT MANAGEMENT LLC | Moderate Conviction | Market Mover | $4,878,822 (0.3%) | 625,490 | 41.1% |
| Bank of New York Mellon Corp | High Conviction | Market Mover | $4,742,340 (0.3%) | 607,992 | - |
| FRANKLIN RESOURCES INC | High Conviction | Market Mover | $4,447,474 (0.3%) | 570,189 | 25.9% |
| FMR LLC | High Conviction | Market Mover | $4,369,421 (0.3%) | 560,182 | -12.0% |
| HILLSDALE INVESTMENT MANAGEMENT INC. | High Conviction | Moderate Flow | $4,360,980 (0.3%) | 559,100 | 2.3% |
| DEUTSCHE BANK AG\\ | Moderate Conviction | Market Mover | $3,830,471 (0.2%) | 491,086 | -52.8% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | High Conviction | Significant Flow | $3,507,995 (0.2%) | 449,743 | -51.7% |
| DAFNA CAPITAL MANAGEMENT LLC | High Conviction | Minimal Flow | $3,262,389 (0.2%) | 418,255 | 96.9% |
| MAN GROUP PLC | High Conviction | Significant Flow | $3,181,230 (0.2%) | 407,850 | 18.2% |
| SWISS NATIONAL BANK | High Conviction | Market Mover | $3,076,070 (0.2%) | 394,368 | 5.2% |
| RAFFERTY ASSET MANAGEMENT, LLC | High Conviction | Significant Flow | $2,983,937 (0.2%) | 382,556 | 6.5% |
| UBS GLOBAL ASSET MANAGEMENT AMERICAS INC | Moderate Conviction | Market Mover | $2,955,053 (0.2%) | 378,853 | - |
| PRINCIPAL FINANCIAL GROUP INC | High Conviction | Market Mover | $2,937,231 (0.2%) | 376,568 | 58.3% |
| FIRST TRUST ADVISORS LP | High Conviction | Market Mover | $2,924,695 (0.2%) | 374,961 | -47.6% |
| ASSENAGON ASSET MANAGEMENT S.A. | High Conviction | Significant Flow | $2,804,724 (0.2%) | 359,580 | -88.1% |
| CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD. | High Conviction | Significant Flow | $2,785,271 (0.2%) | 357,086 | -56.8% |
| STATE OF WISCONSIN INVESTMENT BOARD | High Conviction | Significant Flow | $2,708,082 (0.2%) | 347,190 | -5.1% |
| WALLEYE TRADING ADVISORS, LLC | Moderate Conviction | Significant Flow | $2,632,266 (0.2%) | 337,470 | 52.7% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | High Conviction | Significant Flow | $2,574,148 (0.2%) | 355,055 | 9.7% |
| CANADA PENSION PLAN INVESTMENT BOARD | High Conviction | Significant Flow | $2,557,940 (0.2%) | 327,941 | 46.3% |
| VICTORY CAPITAL MANAGEMENT INC | High Conviction | Market Mover | $2,535,398 (0.2%) | 325,051 | 461.5% |
| FEDERATED HERMES, INC. | High Conviction | Significant Flow | $2,284,230 (0.1%) | 292,850 | 13.4% |
| ALLIANCEBERNSTEIN L.P. | High Conviction | Market Mover | $2,169,882 (0.1%) | 278,190 | 2.7% |
| DOLIVER CAPITAL ADVISORS, LP | High Conviction | Minimal Flow | $2,139,758 (0.1%) | 274,328 | 2.8% |
| RHUMBLINE ADVISERS | High Conviction | Market Mover | $2,079,175 (0.1%) | 266,562 | -16.2% |
| HUSSMAN STRATEGIC ADVISORS, INC. | High Conviction | Minimal Flow | $1,965,600 (0.1%) | 252,000 | 23.3% |
| BRIDGEWATER ASSOCIATES, LP | High Conviction | Significant Flow | $1,837,462 (0.1%) | 235,572 | -41.2% |
| WELLS FARGO & COMPANY/MN | Moderate Conviction | Market Mover | $1,822,384 (0.1%) | 233,639 | 80.5% |
| VIRGINIA RETIREMENT SYSTEMS ET AL | High Conviction | Moderate Flow | $1,820,161 (0.1%) | 233,354 | 112.2% |
| RUSSELL INVESTMENTS GROUP, LTD. | Moderate Conviction | Market Mover | $1,787,965 (0.1%) | 229,226 | -25.1% |
| ENGINEERS GATE MANAGER LP | High Conviction | Moderate Flow | $1,751,435 (0.1%) | 224,543 | -47.9% |
| GOTHAM ASSET MANAGEMENT, LLC | High Conviction | Significant Flow | $1,692,179 (0.1%) | 216,946 | -35.2% |
| LEGAL & GENERAL GROUP PLC | High Conviction | Market Mover | $1,645,792 (0.1%) | 210,999 | -4.1% |
| INTEGRAL HEALTH ASSET MANAGEMENT, LLC | High Conviction | Low Flow | $1,560,000 (0.1%) | 200,000 | NEW |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | High Conviction | Market Mover | $1,496,407 (0.1%) | 191,847 | 8.1% |
| DIADEMA PARTNERS LP | Moderate Conviction | Low Flow | $1,489,238 (0.1%) | 190,928 | NEW |
| ROYAL BANK OF CANADA | High Conviction | Market Mover | $1,260,000 (0.1%) | 161,456 | -67.5% |
| MACKENZIE FINANCIAL CORP | High Conviction | Significant Flow | $1,152,305 (0.1%) | 150,728 | 17.4% |
| PROFUND ADVISORS LLC | High Conviction | Moderate Flow | $1,107,483 (0.1%) | 141,985 | 82.4% |
| SCHONFELD STRATEGIC ADVISORS LLC | High Conviction | Significant Flow | $1,103,302 (0.1%) | 141,449 | -12.9% |
| MILLENNIUM MANAGEMENT, L.L.C. | Moderate Conviction | Market Mover | $1,073,483 (0.1%) | 137,626 | -69.3% |
| RAYMOND JAMES FINANCIAL INC | Moderate Conviction | Market Mover | $1,022,604 (0.1%) | 131,103 | 28.2% |
| QTR Family Wealth, LLC (CIK 0002067954) | High Conviction | Low Flow | $1,009,106 (0.1%) | 154,062 | -15.4% |
| ELO MUTUAL PENSION INSURANCE CO | High Conviction | Moderate Flow | $963,604 (0.1%) | 123,539 | - |
| MIRAE ASSET GLOBAL ETFS HOLDINGS LTD. | High Conviction | Significant Flow | $929,499 (0.1%) | 119,567 | 5.5% |
| HEADLANDS TECHNOLOGIES LLC | High Conviction | Moderate Flow | $924,089 (0.1%) | 118,473 | 6.5% |
| METLIFE INVESTMENT MANAGEMENT, LLC | High Conviction | Significant Flow | $919,253 (0.1%) | 117,853 | 2.7% |
| TUDOR INVESTMENT CORP ET AL | Moderate Conviction | Significant Flow | $893,420 (0.1%) | 114,541 | 19.9% |
| HENNION & WALSH ASSET MANAGEMENT, INC. | High Conviction | Low Flow | $877,804 (0.1%) | 112,539 | 34.9% |
Implied Institutional Price History
Estimated from 13F aggregate market value ÷ shares reported across all institutional filers. Reflects quarter-end snapshot, not actual trade prices.
| Quarter | Filers | Institutional Value | Shares Held | Est. Avg Price |
|---|---|---|---|---|
| Q4 25 | 273 | $1.61B | 210,591,124 | $7.63 |
| Q3 25 | 285 | $1.50B | 202,267,388 | $7.42 |
| Q2 25 | 294 | $1.73B | 200,676,183 | $8.62 |
| Q1 25 | 273 | $1.33B | 182,337,307 | $7.28 |
| Q4 24 | 259 | $1.26B | 172,984,531 | $7.28 |
| Q3 24 | 258 | $1.31B | 181,050,516 | $7.24 |
| Q2 24 | 241 | $1.09B | 183,274,681 | $5.93 |
| Q1 24 | 239 | $0.94B | 191,641,898 | $4.90 |
Source: SEC 13F-HR filings. Implied price = aggregate market value ÷ shares reported. Not investment advice.