KRYS KRYSTAL BIOTECH INC
COM
CUSIP: 501147102
FIGI: BBG00HDGRHH7
Institutional Holders337
Total Institutional Value$6,863,433,921
Total Shares Held28,759,525
Avg Position$20,366,273
Top 5 Holders %55.0%
Alpha-Weighted Score69.0
New Positions+62
Exited Positions-29
Top 15 Institutional Holders by Value
■ New ■ Increased ■ Decreased ■ Unchanged
Institutional Holders — Q4 25
| Manager | Alpha | Flow | Value | Shares | Change |
|---|---|---|---|---|---|
| FMR LLC | High Conviction | Market Mover | $1,072,357,209 (15.6%) | 4,349,628 | 39.9% |
| BLACKROCK FUNDING, INC. /DE | High Conviction | Market Mover | $970,829,404 (14.1%) | 3,937,817 | 43.4% |
| VENBIO SELECT ADVISOR LLC | Elite Conviction | Low Flow | $712,226,448 (10.4%) | 2,888,888 | 45.3% |
| VANGUARD GROUP INC | High Conviction | Market Mover | $685,096,446 (10.0%) | 2,778,845 | 39.0% |
| STATE STREET CORP | High Conviction | Market Mover | $330,931,382 (4.8%) | 1,342,303 | 34.3% |
| SOLEUS CAPITAL MANAGEMENT, L.P. | High Conviction | Low Flow | $232,008,686 (3.4%) | 941,059 | 29.0% |
| CAPITAL WORLD INVESTORS | High Conviction | Market Mover | $199,574,130 (2.9%) | 809,500 | 39.7% |
| REDMILE GROUP, LLC | Elite Conviction | Low Flow | $167,081,391 (2.4%) | 677,705 | 43.1% |
| HOOD RIVER CAPITAL MANAGEMENT LLC | High Conviction | Low Flow | $151,203,475 (2.2%) | 613,302 | 41.1% |
| GEODE CAPITAL MANAGEMENT, LLC | High Conviction | Market Mover | $150,878,011 (2.2%) | 611,878 | 39.8% |
| DIMENSIONAL FUND ADVISORS LP | High Conviction | Market Mover | $121,538,226 (1.8%) | 492,968 | 28.9% |
| FRAZIER LIFE SCIENCES MANAGEMENT, L.P. | Elite Conviction | Low Flow | $120,424,928 (1.8%) | 488,460 | - |
| BELLEVUE GROUP AG | High Conviction | Moderate Flow | $101,161,033 (1.5%) | 410,323 | 43,577.9% |
| CITADEL ADVISORS LLC | Moderate Conviction | Market Mover | $100,910,055 (1.5%) | 409,305 | -16.1% |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | High Conviction | Significant Flow | $92,782,864 (1.4%) | 376,340 | 252.0% |
| GOLDMAN SACHS GROUP INC | High Conviction | Market Mover | $72,365,654 (1.1%) | 293,525 | 17.7% |
| NORGES BANK | High Conviction | Market Mover | $70,158,627 (1.0%) | 284,573 | 57.9% |
| NORTHERN TRUST CORP | High Conviction | Market Mover | $61,004,597 (0.9%) | 247,443 | 39.3% |
| FIRST TRUST ADVISORS LP | High Conviction | Market Mover | $60,470,345 (0.9%) | 245,276 | 37.9% |
| SCHWAB CHARLES INVESTMENT MANAGEMENT INC | High Conviction | Market Mover | $59,853,502 (0.9%) | 242,774 | -32.0% |
| MORGAN STANLEY | Moderate Conviction | Market Mover | $54,604,696 (0.8%) | 221,481 | 31.9% |
| JANUS HENDERSON GROUP PLC | High Conviction | Market Mover | $54,147,221 (0.8%) | 219,440 | 2,944.8% |
| BRAIDWELL LP | High Conviction | Low Flow | $49,825,981 (0.7%) | 202,101 | -45.8% |
| BANK OF AMERICA CORP /DE/ | Moderate Conviction | Market Mover | $47,041,555 (0.7%) | 190,807 | -3.5% |
| Nuveen, LLC | High Conviction | Market Mover | $46,619,235 (0.7%) | 189,094 | 33.8% |
| MARSHALL WACE, LLP | Moderate Conviction | Market Mover | $45,302,711 (0.7%) | 183,754 | 99.0% |
| PRINCIPAL FINANCIAL GROUP INC | High Conviction | Market Mover | $40,697,345 (0.6%) | 165,074 | 61.4% |
| UBS Group AG | Moderate Conviction | Market Mover | $39,346,551 (0.6%) | 159,595 | -20.0% |
| PICTET ASSET MANAGEMENT HOLDING SA | High Conviction | Market Mover | $38,600,275 (0.6%) | 156,568 | 11.1% |
| Bank of New York Mellon Corp | High Conviction | Market Mover | $37,304,704 (0.5%) | 151,313 | 35.9% |
| WOODLINE PARTNERS LP | High Conviction | Significant Flow | $37,132,869 (0.5%) | 150,616 | 39.7% |
| JPMORGAN CHASE & CO | High Conviction | Market Mover | $33,190,200 (0.5%) | 134,624 | -35.8% |
| FRANKLIN RESOURCES INC | High Conviction | Market Mover | $30,983,914 (0.5%) | 125,675 | 784.2% |
| CAPTION MANAGEMENT, LLC | Moderate Conviction | Significant Flow | $30,891,462 (0.5%) | 125,300 | 66.7% |
| ORBIMED ADVISORS LLC | High Conviction | Low Flow | $29,535,492 (0.4%) | 119,800 | 62.8% |
| VOYA INVESTMENT MANAGEMENT LLC | Moderate Conviction | Market Mover | $25,457,967 (0.4%) | 103,261 | 53.6% |
| TIMESSQUARE CAPITAL MANAGEMENT, LLC | High Conviction | Low Flow | $24,012,996 (0.3%) | 97,400 | 14.8% |
| S SQUARED TECHNOLOGY, LLC | Elite Conviction | Minimal Flow | $23,720,846 (0.3%) | 96,215 | 23.0% |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | High Conviction | Significant Flow | $22,031,307 (0.3%) | 89,362 | 24.3% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Moderate Conviction | Market Mover | $21,391,536 (0.3%) | 86,767 | -52.7% |
| SEGALL BRYANT & HAMILL | High Conviction | Moderate Flow | $20,523,469 (0.3%) | 83,246 | 36.4% |
| RAYMOND JAMES FINANCIAL INC | Moderate Conviction | Market Mover | $18,965,766 (0.3%) | 76,538 | 66.9% |
| BIONDO INVESTMENT ADVISORS, LLC | High Conviction | Minimal Flow | $16,796,770 (0.2%) | 68,130 | 83.4% |
| RHUMBLINE ADVISERS | High Conviction | Market Mover | $16,379,100 (0.2%) | 66,436 | 31.5% |
| LEGAL & GENERAL GROUP PLC | High Conviction | Market Mover | $15,621,020 (0.2%) | 63,361 | 34.5% |
| BARCLAYS PLC | High Conviction | Market Mover | $14,807,687 (0.2%) | 60,062 | 10.5% |
| Invesco Ltd. | Moderate Conviction | Market Mover | $14,794,373 (0.2%) | 60,008 | 25.3% |
| JANE STREET GROUP, LLC | Moderate Conviction | Market Mover | $13,362,468 (0.2%) | 54,200 | 13.4% |
| TD ASSET MANAGEMENT INC | High Conviction | Significant Flow | $13,348,169 (0.2%) | 54,142 | 67.7% |
| BNP PARIBAS FINANCIAL MARKETS | Moderate Conviction | Market Mover | $13,291,218 (0.2%) | 53,911 | 720.3% |
| AMERIPRISE FINANCIAL INC | Moderate Conviction | Market Mover | $12,905,135 (0.2%) | 52,345 | 31.0% |
| SKANDINAVISKA ENSKILDA BANKEN AB (PUBL) | High Conviction | Significant Flow | $11,521,307 (0.2%) | 46,732 | 8.8% |
| SWISS NATIONAL BANK | High Conviction | Market Mover | $10,576,566 (0.2%) | 42,900 | 42.7% |
| PALISADES INVESTMENT PARTNERS, LLC | High Conviction | Minimal Flow | $10,543,283 (0.2%) | 42,765 | 44.3% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | High Conviction | Market Mover | $10,055,660 (0.1%) | 40,629 | 65.3% |
| ADAR1 CAPITAL MANAGEMENT, LLC | High Conviction | Low Flow | $9,868,504 (0.1%) | 40,028 | 201.8% |
| STANDARD LIFE ABERDEEN PLC | High Conviction | Significant Flow | $9,703,814 (0.1%) | 39,360 | -7.4% |
| CORIENT PRIVATE WEALTH LLC | High Conviction | Market Mover | $9,502,070 (0.1%) | 38,290 | -23.9% |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | High Conviction | Moderate Flow | $9,188,299 (0.1%) | 37,269 | 37.2% |
| FEDERATED HERMES, INC. | High Conviction | Significant Flow | $8,515,738 (0.1%) | 34,541 | 101.2% |
| HEALTHINVEST PARTNERS AB | High Conviction | Minimal Flow | $8,346,118 (0.1%) | 33,853 | 955.5% |
| UBS GLOBAL ASSET MANAGEMENT AMERICAS INC | Moderate Conviction | Market Mover | $8,287,936 (0.1%) | 33,617 | -76.8% |
| SEI INVESTMENTS CO | High Conviction | Market Mover | $7,965,738 (0.1%) | 32,310 | 92.9% |
| WELLS FARGO & COMPANY/MN | Moderate Conviction | Market Mover | $7,783,760 (0.1%) | 31,572 | 124.4% |
| ALLIANCEBERNSTEIN L.P. | High Conviction | Market Mover | $7,773,160 (0.1%) | 31,529 | 47.2% |
| NEW YORK STATE COMMON RETIREMENT FUND | High Conviction | Market Mover | $7,727,057 (0.1%) | 31,342 | -80.8% |
| CITIGROUP INC | Moderate Conviction | Market Mover | $7,382,148 (0.1%) | 29,943 | 316.1% |
| CASTLEARK MANAGEMENT LLC | High Conviction | Moderate Flow | $7,213,760 (0.1%) | 29,260 | NEW |
| RUSSELL INVESTMENTS GROUP, LTD. | Moderate Conviction | Market Mover | $7,138,368 (0.1%) | 28,954 | 52.3% |
| PRUDENTIAL FINANCIAL INC | High Conviction | Significant Flow | $6,660,278 (0.1%) | 27,015 | 48.0% |
| VICTORY CAPITAL MANAGEMENT INC | High Conviction | Market Mover | $6,523,695 (0.1%) | 26,461 | -32.6% |
| GRANITE INVESTMENT PARTNERS, LLC | High Conviction | Low Flow | $6,350,870 (0.1%) | 25,760 | NEW |
| RHENMAN & PARTNERS ASSET MANAGEMENT AB | High Conviction | Low Flow | $6,163,500 (0.1%) | 25,000 | 197.2% |
| EUDAIMONIA ASSET MANAGEMENT LLC | Moderate Conviction | Low Flow | $6,081,402 (0.1%) | 24,667 | NEW |
| RAFFERTY ASSET MANAGEMENT, LLC | High Conviction | Significant Flow | $5,983,033 (0.1%) | 24,268 | -2.2% |
| DEUTSCHE BANK AG\\ | Moderate Conviction | Market Mover | $5,534,822 (0.1%) | 22,450 | 46.7% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | High Conviction | Market Mover | $5,074,533 (0.1%) | 20,583 | 37.7% |
| FIERA SCEPTRE INC. | High Conviction | Moderate Flow | $4,649,005 (0.1%) | 18,857 | 74.8% |
| GOODMAN & COMPANY, INVESTMENT COUNSEL LTD. | High Conviction | Significant Flow | $4,339,104 (0.1%) | 17,600 | NEW |
| PERCEPTIVE ADVISORS LLC | High Conviction | Low Flow | $4,314,450 (0.1%) | 17,500 | -30.2% |
| DECHENG CAPITAL LLC | Elite Conviction | Minimal Flow | $4,265,142 (0.1%) | 17,300 | -25.2% |
| VERITION FUND MANAGEMENT LLC | High Conviction | Significant Flow | $4,183,537 (0.1%) | 16,969 | -24.4% |
| EVOLUTIONARY TREE CAPITAL MANAGEMENT, LLC | High Conviction | Minimal Flow | $4,144,584 (0.1%) | 16,811 | 88.4% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | High Conviction | Significant Flow | $3,884,484 (0.1%) | 15,756 | 280.4% |
| J. GOLDMAN & CO LP | Moderate Conviction | Moderate Flow | $3,731,383 (0.1%) | 15,135 | NEW |
| IKARIAN CAPITAL, LLC | High Conviction | Low Flow | $3,652,243 (0.1%) | 14,814 | -15.3% |
| MILLENNIUM MANAGEMENT, L.L.C. | Moderate Conviction | Market Mover | $3,613,783 (0.1%) | 14,658 | -86.2% |
| STATE OF WISCONSIN INVESTMENT BOARD | High Conviction | Significant Flow | $3,566,448 (0.1%) | 14,466 | -31.1% |
| AQR CAPITAL MANAGEMENT LLC | High Conviction | Market Mover | $3,490,268 (0.1%) | 14,157 | - |
| CREATIVE PLANNING | High Conviction | Significant Flow | $3,422,222 (0.0%) | 13,881 | 67.0% |
| METLIFE INVESTMENT MANAGEMENT, LLC | High Conviction | Significant Flow | $3,413,100 (0.0%) | 13,844 | 34.0% |
| CREDIT AGRICOLE S A | High Conviction | Significant Flow | $3,199,103 (0.0%) | 12,976 | NEW |
| MIRAE ASSET GLOBAL ETFS HOLDINGS LTD. | High Conviction | Significant Flow | $3,195,584 (0.0%) | 12,954 | 36.2% |
| ILLINOIS MUNICIPAL RETIREMENT FUND | High Conviction | Moderate Flow | $3,130,811 (0.0%) | 12,699 | 24.5% |
| PRIVIUM FUND MANAGEMENT B.V. | Elite Conviction | Minimal Flow | $3,000,392 (0.0%) | 12,170 | 39.7% |
| BRIDGE CITY CAPITAL, LLC | High Conviction | Minimal Flow | $2,991,763 (0.0%) | 12,135 | 19.7% |
| TORRAY ROBERT E & CO INC | High Conviction | Minimal Flow | $2,954,782 (0.0%) | 11,985 | 40.6% |
| TFG ASSET MANAGEMENT GP LTD | High Conviction | Minimal Flow | $2,912,624 (0.0%) | 11,814 | 238.8% |
| LOUISIANA STATE EMPLOYEES RETIREMENT SYSTEM | High Conviction | Moderate Flow | $2,909,172 (0.0%) | 11,800 | 39.7% |
| STATE OF TENNESSEE, TREASURY DEPARTMENT | High Conviction | Significant Flow | $2,846,294 (0.0%) | 10,193 | 45.0% |
Implied Institutional Price History
Estimated from 13F aggregate market value ÷ shares reported across all institutional filers. Reflects quarter-end snapshot, not actual trade prices.
| Quarter | Filers | Institutional Value | Shares Held | Est. Avg Price |
|---|---|---|---|---|
| Q4 25 | 335 | $6.86B | 28,761,253 | $238.65 |
| Q3 25 | 286 | $5.14B | 29,977,551 | $171.46 |
| Q2 25 | 275 | $3.83B | 28,646,407 | $133.64 |
| Q1 25 | 302 | $4.92B | 28,635,453 | $171.91 |
| Q4 24 | 268 | $4.35B | 29,056,543 | $149.87 |
| Q3 24 | 283 | $5.24B | 30,391,333 | $172.38 |
| Q2 24 | 249 | $5.26B | 30,563,651 | $171.97 |
| Q1 24 | 243 | $4.63B | 28,394,458 | $163.16 |
Source: SEC 13F-HR filings. Implied price = aggregate market value ÷ shares reported. Not investment advice.