AMLX AMYLYX PHARMACEUTICALS INC
COM
CUSIP: 03237H101
FIGI: BBG00DP10YT5
Institutional Holders187
Total Institutional Value$1,366,943,850
Total Shares Held113,579,607
Avg Position$7,309,860
Top 5 Holders %40.6%
Alpha-Weighted Score70.3
New Positions+34
Exited Positions-26
Top 15 Institutional Holders by Value
■ New ■ Increased ■ Decreased ■ Unchanged
Institutional Holders — Q4 25
| Manager | Alpha | Flow | Value | Shares | Change |
|---|---|---|---|---|---|
| FMR LLC | High Conviction | Market Mover | $199,542,502 (14.6%) | 16,518,419 | 29.0% |
| BLACKROCK FUNDING, INC. /DE | High Conviction | Market Mover | $109,377,525 (8.0%) | 9,054,431 | 12.7% |
| PERCEPTIVE ADVISORS LLC | High Conviction | Low Flow | $100,081,375 (7.3%) | 8,284,882 | -17.7% |
| TCG CROSSOVER MANAGEMENT, LLC | Elite Conviction | Low Flow | $75,425,249 (5.5%) | 6,243,812 | -11.1% |
| VANGUARD GROUP INC | High Conviction | Market Mover | $70,123,336 (5.1%) | 5,804,912 | -2.2% |
| COMMODORE CAPITAL LP | Elite Conviction | Low Flow | $68,252,000 (5.0%) | 5,650,000 | 23.2% |
| SATURN V CAPITAL MANAGEMENT LP | Elite Conviction | Minimal Flow | $54,317,563 (4.0%) | 4,496,487 | -13.2% |
| JANUS HENDERSON GROUP PLC | High Conviction | Market Mover | $53,992,392 (3.9%) | 4,465,872 | 56.7% |
| FIRST LIGHT ASSET MANAGEMENT, LLC | Elite Conviction | Low Flow | $40,534,911 (3.0%) | 3,355,539 | -11.1% |
| DRIEHAUS CAPITAL MANAGEMENT LLC | High Conviction | Moderate Flow | $37,562,796 (2.7%) | 3,109,503 | 14.2% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | High Conviction | Significant Flow | $33,546,824 (2.5%) | 2,777,055 | -63.8% |
| GOLDMAN SACHS GROUP INC | High Conviction | Market Mover | $31,567,709 (2.3%) | 2,613,221 | 15.5% |
| MORGAN STANLEY | Moderate Conviction | Market Mover | $28,506,673 (2.1%) | 2,359,824 | 7.6% |
| GEODE CAPITAL MANAGEMENT, LLC | High Conviction | Market Mover | $26,163,536 (1.9%) | 2,165,534 | 6.2% |
| ALMITAS CAPITAL LLC | Elite Conviction | Minimal Flow | $25,640,972 (1.9%) | 2,122,597 | -55.6% |
| STATE STREET CORP | High Conviction | Market Mover | $25,004,199 (1.8%) | 2,069,884 | 13.5% |
| ADAR1 CAPITAL MANAGEMENT, LLC | High Conviction | Low Flow | $21,511,000 (1.6%) | 1,780,712 | 82.7% |
| GREAT POINT PARTNERS LLC | High Conviction | Minimal Flow | $21,140,000 (1.5%) | 1,750,000 | -8.5% |
| 683 CAPITAL MANAGEMENT, LLC | High Conviction | Low Flow | $19,932,000 (1.5%) | 1,650,000 | -16.7% |
| EVENTIDE ASSET MANAGMENT LLC | High Conviction | Moderate Flow | $18,278,773 (1.3%) | 1,513,148 | -11.1% |
| BANK OF AMERICA CORP /DE/ | Moderate Conviction | Market Mover | $16,139,001 (1.2%) | 1,336,010 | 38.2% |
| DEUTSCHE BANK AG\\ | Moderate Conviction | Market Mover | $16,105,491 (1.2%) | 1,333,236 | -13.2% |
| FRANKLIN RESOURCES INC | High Conviction | Market Mover | $14,497,160 (1.1%) | 1,200,096 | NEW |
| CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD. | High Conviction | Significant Flow | $12,128,574 (0.9%) | 1,004,021 | -19.4% |
| LOGOS GLOBAL MANAGEMENT LP | High Conviction | Low Flow | $11,476,000 (0.8%) | 950,000 | -41.8% |
| NORTHERN TRUST CORP | High Conviction | Market Mover | $11,328,189 (0.8%) | 937,764 | - |
| BALYASNY ASSET MANAGEMENT LLC | Moderate Conviction | Market Mover | $10,372,903 (0.8%) | 858,684 | -48.3% |
| WOODLINE PARTNERS LP | High Conviction | Significant Flow | $10,212,529 (0.7%) | 845,408 | -11.1% |
| NANTAHALA CAPITAL MANAGEMENT, LLC | High Conviction | Low Flow | $10,095,063 (0.7%) | 835,684 | -20.6% |
| Boxer Capital Management, LLC | High Conviction | Minimal Flow | $9,664,000 (0.7%) | 800,000 | -21.0% |
| DIMENSIONAL FUND ADVISORS LP | High Conviction | Market Mover | $9,316,092 (0.7%) | 771,248 | 34.3% |
| SCHWAB CHARLES INVESTMENT MANAGEMENT INC | High Conviction | Market Mover | $8,612,919 (0.6%) | 712,990 | -14.6% |
| STEMPOINT CAPITAL LP | High Conviction | Minimal Flow | $6,826,891 (0.5%) | 565,140 | 81.5% |
| UBS Group AG | Moderate Conviction | Market Mover | $6,563,342 (0.5%) | 543,323 | -65.6% |
| SOFINNOVA VENTURES INC | Elite Conviction | Low Flow | $6,367,356 (0.5%) | 527,099 | NEW |
| SILVERARC CAPITAL MANAGEMENT, LLC | High Conviction | Minimal Flow | $6,115,403 (0.4%) | 506,242 | -35.7% |
| AMERIPRISE FINANCIAL INC | Moderate Conviction | Market Mover | $6,068,581 (0.4%) | 502,366 | 234.5% |
| ROCK SPRINGS CAPITAL MANAGEMENT LP | High Conviction | Low Flow | $6,037,149 (0.4%) | 499,764 | -11.1% |
| FEDERATED HERMES, INC. | High Conviction | Significant Flow | $5,525,537 (0.4%) | 457,412 | 91.4% |
| CITADEL ADVISORS LLC | Moderate Conviction | Market Mover | $5,518,965 (0.4%) | 456,868 | 9.2% |
| QUBE RESEARCH & TECHNOLOGIES LTD | Moderate Conviction | Market Mover | $4,987,506 (0.4%) | 412,873 | 119.6% |
| CORMORANT ASSET MANAGEMENT, LP | High Conviction | Low Flow | $4,832,000 (0.4%) | 400,000 | -28.9% |
| PARKMAN HEALTHCARE PARTNERS LLC | High Conviction | Low Flow | $4,611,661 (0.3%) | 381,760 | -41.4% |
| PATIENT SQUARE CAPITAL LP | Elite Conviction | Minimal Flow | $4,228,000 (0.3%) | 350,000 | - |
| TWO SIGMA INVESTMENTS, LP | Moderate Conviction | Significant Flow | $4,160,364 (0.3%) | 344,401 | 211.1% |
| POINT72 ASSET MANAGEMENT, L.P. | Moderate Conviction | Market Mover | $4,046,800 (0.3%) | 335,000 | -89.3% |
| LONGWOOD CAPITAL PARTNERS LLC | Elite Conviction | Minimal Flow | $4,025,757 (0.3%) | 333,258 | -11.1% |
| TWO SIGMA ADVISERS, LP | High Conviction | Significant Flow | $3,967,084 (0.3%) | 328,401 | 104.1% |
| FALCON EDGE CAPITAL, LP | Elite Conviction | Minimal Flow | $3,837,550 (0.3%) | 317,678 | -13.7% |
| JANE STREET GROUP, LLC | Moderate Conviction | Market Mover | $3,677,575 (0.3%) | 304,435 | 415.5% |
| BARCLAYS PLC | High Conviction | Market Mover | $3,565,738 (0.3%) | 295,177 | -36.6% |
| Nuveen, LLC | High Conviction | Market Mover | $3,430,092 (0.3%) | 283,948 | 57.3% |
| TFG ASSET MANAGEMENT GP LTD | High Conviction | Minimal Flow | $3,295,762 (0.2%) | 272,828 | -6.1% |
| HIGHVISTA STRATEGIES LLC | High Conviction | Minimal Flow | $2,884,849 (0.2%) | 238,812 | NEW |
| WELLINGTON MANAGEMENT GROUP LLP | High Conviction | Market Mover | $2,727,447 (0.2%) | 225,782 | -15.0% |
| SummitTX Capital, L.P. | High Conviction | Moderate Flow | $2,638,260 (0.2%) | 218,399 | 15.6% |
| Bank of New York Mellon Corp | High Conviction | Market Mover | $2,625,551 (0.2%) | 217,347 | 5.6% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Moderate Conviction | Market Mover | $2,402,615 (0.2%) | 198,892 | -40.6% |
| ALDEBARAN CAPITAL, LLC | High Conviction | Minimal Flow | $2,397,977 (0.2%) | 198,508 | -13.7% |
| RENAISSANCE TECHNOLOGIES LLC | High Conviction | Significant Flow | $2,325,400 (0.2%) | 192,500 | 759.9% |
| XTX TOPCO LTD | Moderate Conviction | Moderate Flow | $2,291,250 (0.2%) | 189,673 | NEW |
| Invesco Ltd. | Moderate Conviction | Market Mover | $2,125,041 (0.2%) | 175,914 | -80.7% |
| SWISS NATIONAL BANK | High Conviction | Market Mover | $1,953,336 (0.1%) | 161,700 | NEW |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | High Conviction | Significant Flow | $1,852,625 (0.1%) | 153,363 | NEW |
| WELLS FARGO & COMPANY/MN | Moderate Conviction | Market Mover | $1,767,411 (0.1%) | 146,309 | 38.8% |
| ATOM INVESTORS LP | High Conviction | Moderate Flow | $1,684,218 (0.1%) | 139,422 | NEW |
| BANK OF MONTREAL /CAN/ | High Conviction | Market Mover | $1,673,382 (0.1%) | 138,525 | -14.3% |
| PFM HEALTH SCIENCES, LP | High Conviction | Low Flow | $1,625,352 (0.1%) | 134,549 | -72.6% |
| NUMERAI, LLC | High Conviction | Low Flow | $1,360,788 (0.1%) | 112,648 | 49.1% |
| RHUMBLINE ADVISERS | High Conviction | Market Mover | $1,199,221 (0.1%) | 99,274 | -10.6% |
| UBS GLOBAL ASSET MANAGEMENT AMERICAS INC | Moderate Conviction | Market Mover | $1,193,963 (0.1%) | 98,838 | NEW |
| ALPS ADVISORS INC | High Conviction | Moderate Flow | $1,089,278 (0.1%) | 90,172 | NEW |
| STATE OF WISCONSIN INVESTMENT BOARD | High Conviction | Significant Flow | $1,016,460 (0.1%) | 84,144 | 439.1% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | High Conviction | Market Mover | $955,407 (0.1%) | 79,090 | 1,523.2% |
| CAMPBELL & CO INVESTMENT ADVISER LLC | High Conviction | Moderate Flow | $951,457 (0.1%) | 78,763 | 186.0% |
| SQUAREPOINT OPS LLC | Moderate Conviction | Significant Flow | $924,869 (0.1%) | 76,562 | NEW |
| SHAW D E & CO INC | Moderate Conviction | Market Mover | $884,546 (0.1%) | 73,224 | -5.5% |
| LEGAL & GENERAL GROUP PLC | High Conviction | Market Mover | $877,153 (0.1%) | 72,612 | -4.0% |
| ALLIANCEBERNSTEIN L.P. | High Conviction | Market Mover | $863,720 (0.1%) | 71,500 | -11.1% |
| JPMORGAN CHASE & CO | High Conviction | Market Mover | $803,888 (0.1%) | 66,547 | -17.5% |
| RUSSELL INVESTMENTS GROUP, LTD. | Moderate Conviction | Market Mover | $790,491 (0.1%) | 65,438 | 5.0% |
| Persistent Asset Partners Ltd | Moderate Conviction | Minimal Flow | $687,644 (0.1%) | 54,060 | 120.8% |
| Kennondale Capital Management LLC | High Conviction | Minimal Flow | $645,350 (0.0%) | 53,423 | -56.3% |
| EUDAIMONIA ASSET MANAGEMENT LLC | Moderate Conviction | Low Flow | $643,332 (0.0%) | 53,256 | -37.0% |
| SEI INVESTMENTS CO | High Conviction | Market Mover | $638,500 (0.0%) | 52,856 | NEW |
| METLIFE INVESTMENT MANAGEMENT, LLC | High Conviction | Significant Flow | $599,820 (0.0%) | 49,654 | 2.8% |
| TREXQUANT INVESTMENT LP | High Conviction | Significant Flow | $581,193 (0.0%) | 48,112 | -80.8% |
| MILLENNIUM MANAGEMENT, L.L.C. | Moderate Conviction | Market Mover | $561,176 (0.0%) | 46,455 | -90.1% |
| MARINER, LLC | High Conviction | Market Mover | $559,858 (0.0%) | 46,342 | -14.2% |
| WALLEYE TRADING ADVISORS, LLC | Moderate Conviction | Significant Flow | $558,579 (0.0%) | 46,240 | 41.7% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS LTD. | High Conviction | Significant Flow | $497,285 (0.0%) | 41,166 | 14.4% |
| CITIGROUP INC | Moderate Conviction | Market Mover | $459,427 (0.0%) | 38,032 | -11.2% |
| ZURCHER KANTONALBANK | High Conviction | Significant Flow | $433,394 (0.0%) | 35,877 | 1,573.1% |
| FOX RUN MANAGEMENT, L.L.C. | Moderate Conviction | Low Flow | $427,741 (0.0%) | 35,409 | NEW |
| INTECH INVESTMENT MANAGEMENT LLC | High Conviction | Significant Flow | $386,632 (0.0%) | 32,006 | 45.9% |
| HEADLANDS TECHNOLOGIES LLC | High Conviction | Moderate Flow | $368,959 (0.0%) | 30,543 | NEW |
| VERITION FUND MANAGEMENT LLC | High Conviction | Significant Flow | $356,203 (0.0%) | 29,487 | -59.0% |
| AQR CAPITAL MANAGEMENT LLC | High Conviction | Market Mover | $336,391 (0.0%) | 27,847 | -66.4% |
| Integrated Quantitative Investments LLC (CIK 0002046834) | Moderate Conviction | Low Flow | $328,987 (0.0%) | 27,234 | NEW |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | High Conviction | Market Mover | $326,015 (0.0%) | 26,988 | - |
Implied Institutional Price History
Estimated from 13F aggregate market value ÷ shares reported across all institutional filers. Reflects quarter-end snapshot, not actual trade prices.
| Quarter | Filers | Institutional Value | Shares Held | Est. Avg Price |
|---|---|---|---|---|
| Q4 25 | 179 | $1.37B | 113,579,607 | $12.04 |
| Q3 25 | 170 | $1.52B | 113,431,570 | $13.36 |
| Q2 25 | 130 | $0.52B | 82,062,261 | $6.32 |
| Q1 25 | 134 | $0.31B | 87,276,620 | $3.51 |
| Q4 24 | 123 | $0.19B | 51,970,605 | $3.71 |
| Q3 24 | 111 | $0.14B | 45,876,182 | $3.07 |
| Q2 24 | 121 | $0.09B | 47,604,397 | $1.83 |
| Q1 24 | 151 | $0.19B | 68,204,900 | $2.75 |
Source: SEC 13F-HR filings. Implied price = aggregate market value ÷ shares reported. Not investment advice.